protein ,response — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23189	Prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]		Others
	Prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens] is a peptide with the sequence H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH, MW= 623.66.		Others
T4304	Azoramide		Apoptosis , PERK
	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.		Apoptosis , PERK
T9349	IXA4		IRE1
	IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.		IRE1
T8464	RA-9		Apoptosis , DUB
	RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.		Apoptosis , DUB
T9110	Ceapin-A7		Others
	Ceapin-A7, with an IC50 of 0.59 μM, selectively inhibits ATF6α signaling in response to ER stress. This compound is instrumental in investigating ATF6α's activation mechanism and its function in pathological conditions.		Others
T23384	SR 11302		DNA/RNA Synthesis
	SR 11302 is an inhibitor of activator protein-1 (AP-1).		DNA/RNA Synthesis
T3594	ML346		HSP
	ML346 is a novel activator of Hsp70.		HSP
TQ0302	Thapsigargin		Apoptosis , SARS-CoV , Calcium Channel
	Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ...		Apoptosis , SARS-CoV , Calcium Channel
T6859	I-BRD9	GSK602	Epigenetic Reader Domain
	I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3.		Epigenetic Reader Domain
T13693	Fibrin		Others
	Fibrin, the primary constituent of blood clots, is an insoluble protein essential for coagulation. Isolated from bovine blood, this protein is notably synthesized in response to bleeding.		Others
T39980	ErSO		Others
	ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.		Others
T29842	Alclofenac	W 7320,MY 101,BRN 2116510,W-7320,W7320	Others
	Alclofenac (W-7320) has a significant effect on the acute phase protein response and the degree of L-tryptophan binding to plasma protein and can be used in the treatment of patients with chronic rheumatism.		Others
T7297	KG-501	Naphthol AS-E phosphate	Epigenetic Reader Domain
	KG-501 (Naphthol AS-E phosphate) is a cAMP response element-binding protein (CREB) inhibitor(IC50 : 6.89 μM).		Epigenetic Reader Domain
TQ0121	VH-298		Others , HIF , Ligand for E3 Ligase
	VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by P...		Others , HIF , Ligand for E3 Ligase
TP1876L	CREBtide acetate(149155-45-3 free base)		PKA
	CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).		PKA
T8890	653-47 hydrochloride		Epigenetic Reader Domain
	653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.		Epigenetic Reader Domain
TP1051L	Protein Kinase C Peptide Substrate acetate	Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)	Others
	Protein Kinase C Peptide Substrate acetate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-couple...		Others
T23095	NU 9056	NU9056	Histone Acetyltransferase
	NU 9056 is an effective and selective inhibitor of KAT5 histone acetyltransferase with an IC50 of 2 µM. NU 9056 blocks DNA damage response and inhibits protein acetylation in prostate cancer cell lines.		Histone Acetyltransferase
TP1592L	C-Reactive Protein (CRP) 174-185 acetate	C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base)	Others
	C-Reactive Protein (CRP) 174-185 acetate is an acute phase serum protein synthesized in response to inflammatory cytokines, produces antitumor effects in animals. The fragment CRP (174-185) (RS-83277) shows similar activ...		Others
T60857	MKK7-COV-9		Others
	MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 s...		Others